November is Pet Diabetes Awareness Month

Diabetes mellitus (DM) is a common disease in the United States, and it's not limited to people. Both dogs and cats can become diabetic, so here's what you need to know.

1. There are 2 types of diabetes, and they both affect insulin. Insulin is a hormone produced in the pancreas that regulates the amount of glucose in the blood. Cells need insulin in order to absorb the glucose they need for energy.

• Type I diabetes is where the pancreas stops producing enough insulin. Dogs usually acquire this type of DM. They will need treatment for life.
• Type II diabetes is where insulin is being produced but the cells don't respond to it. Cats are most likely to acquire this type of DM.  Some cats can regain insulin sensitivity with treatment and may not need lifelong medication.

2. Signs of Diabetes - consider diabetes if your pet is showing any of these symptoms

• increased thirst
• increased urine production, sometimes leading to house-soiling
• increased hunger
• weight loss (especially the back muscles, even if the belly is still large)
• vomiting
• weakness or lethargy
• white-appearing eyes (diabetes often leads to cataracts)
• blindness
• poor skin or coat condition (flakes, dandruff, or greasiness)

3. Diagnosing Diabetes
If your pet is showing any of these signs, blood and urine tests can make the diagnosis of diabetes and rule out complications that require hospitalization before starting insulin at home.

4. Treatment of Diabetes
Insulin therapy and diet change are the mainstays of diabetic management. Cats and dogs respond better to different types of insulin, and most require twice daily insulin injections. Your veterinarian will work closely with you to make sure you are comfortable handling the syringe, drawing up the medication, and giving the injections. Be prepared to see a lot of your veterinarian in the initial stages while we adjust the dose to best treat your pet. We will measure the blood sugar at certain points in time to make sure that the level is never too high or too low. If you are comfortable measuring blood glucose at home then we can teach you which monitor is most accurate for pets and how to get the blood sample you'll need.
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Diabetic dogs tend to do best with a high fiber diet. Cats, however, will respond best to a high protein diet. Some cats can even stop needing their insulin injections (achieving remission) after their diet is changed and they've been treated for a few months, although they still require periodic monitoring because the DM can recur later. 

5. Complications

• Hypoglycemia (low blood sugar) is the most urgent of the potential complications. This can cause weakness, coma, seizures, and even death. We slowly adjust insulin dosing to avoid this complication, but if your diabetic pet is not responding to you quickly drop honey, maple syrup, or karo syrup on the gums to get some sugar absorbed quickly and then seek emergency care.
• Diabetic ketoacidosis is a life-threatening state where the body has started metabolizing proteins for energy because it can't use the glucose. This happens in untreated and sometimes in under-treated pets. These pets feel ill, may start vomiting, get severely dehydrated, and usually need hospitalization with fluid therapy in order to recover.
• Urinary tract infections are a frequent side effect of diabetes. Because the urine of diabetic cats and dogs will contain sugar when their blood glucose climbs higher than 180, it can allow bacteria to grow much more easily than normal urine. Diabetics also frequently don't mount a good immune response to the infection, so they can't clear the bacteria on their own. These infections can be hard to detect at home when your pet is already drinking and urinating more than usual from the diabetes. Regular urine cultures are the best way to identify these infections and then start antibiotics when needed. 
• Cataracts can occur rapidly in diabetic dogs, and but almost never in diabetic cats. 80% of diabetic dogs will develop cataracts within a year of their diagnosis.  This happens because the glucose in the blood also enters the fluid of the eye, and the excess is converted to sorbitol. Sorbitol then draws water into the lens, disrupting its architecture and causing cloudiness. The lens of the eye eventually appears white and causes blindness in that eye. Surgery is the only treatment to regain vision, and can be performed by a veterinary ophthalmologist once the diabetes is controlled. Anti-inflammatory eye drops should be used once a cataract appears in order to decrease inflammation in the eye from the leaky lens proteins. There is a new topical eye medication called Kinostat under development that may prevent this process, but research is still being conducted.

Despite these complications, the bottom line is that a diabetic dog or cat can still have a good life. They definitely require a lot of extra care for their nutrition and insulin injections, and the early months can be very frustrating until the right type of insulin at the right dose is found for your particular pet. But we find that most diabetic pets can be well managed at home and just need regular checkups to keep them on the right track.

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